SUPER AWESOME TEST REVIEWThis is a featured page

FYI there is a another review page as well, you may want to combine
It's under the exam topics to know.

http://humannutrition.wetpaint.com/page/Exam+1+Review


Types of Nutrition Research

Epidemiology:study of human populations

Cross Sectional: “Snapshot” of the present in different Geological Locations
Case Control: Retrospective - compares diet factors against a control, decreases the likely hood that a difference in the study is not due to chance, measures deviation from the neutral (1) in p-values, a p-value deviation of p<0.05 is considered significant
Cohort: a group of individuals is selected and followed over a long period of time
Retrospective: not commonly used
Prospective: more commonly used. Looks from the baseline (beginning of study) into the future.
Clinical Trial: large study using above methods. Usually cost quite a bit of money, but is very reliable. It is done with humans rather than animals so the results are more reliable, but can't always be done because it may not be safe to be test on humans.

Nutrition Evidence, Why Research is performed, and Why it is important
Research is performed to test a theory or hunch. Different types of research can be performed (ie in vitro, in vivo, and cell cultures) but this information cannot be accepted by the professional community until it is tested and retested to verify the results. This information has to be valid and tested true in order to be accepted by the scientific community. The strength of the research is also important; Systematic literature reviews are the most reliable.

Publishing a Research Article
Research articles should be sent out to at least two expert researchers for peer review. It must be research that is valid and worth being published or it will be torn apart. The researcher puts together an intro, abstract, methods, experiment, results and conclusion. Then they send it to an editor who sends it to two professional researchers who will perform the tests. Once the process if done it is a "peer-reviewed" journal.

Amylose, Amylopectin, & Glycogen

Amylose – Linear Starch - comes from plants
Amylopectin – Linear at α1,4 bonds and branched at α1,6 bonds, comes from plantsThickening Agent
Glycogen – Animal storage form of energy, rapidly degraded after slaughter, more branching than Amylopectin but in the same positions.

Starch vs. Fiber
Both made of glucose molecules BUT Starch has α-bonds while Fiber has β-bonds
Classes of Fiber
Fiber Description
Nonfermentable, Nonviscous (Insoluble)
Cellulose Main component of plant cell walls
Hemicelluloses Surround cellulose in plant cell walls
Lignin Noncarbohydrate, found within “woody” plant cell walls
Fermentable, Viscous (Soluble)
Hemicelluloses Surround cellulose in plant cell walls
Pectin Found in cell walls and intracellular
tissues of fruits and berries
β-glucans -
Gums Viscous, usually isolated from seeds


Dietary vs. Functional Fiber
Dietary Fiber: Only in plants and are fully intact plant cells
Functional Fiber: Are Isolated, extracted, or synthesized, can be from animals, and has to show a beneficial physiological effect in humans

Naming (Omega ω) Saturated and Unsaturated Fatty Acids

Start with the total number of carbons in the fatty acid chain (18), followed with a colon ( : ), then the total number of double bonds within the fatty acid (1), the Omega symbol (ω), a hyphen (-) and the carbon on which the double bond is oriented (9). (***The number one carbon will be the CH₃ or Methyl End***) See Slide for picture

Hydrogenation
Hydrogenation is when a fatty acid chain that does not contain its full number of hydrogen’s per carbon (aka unsaturated) is chemically changed (all C=C double bonds are broken) and becomes fully hydrogenated (aka saturated). In this form, the fatty acid is resistant to oxidation and is solid at room temperature.
-unsaturated bond--(adds Hydrogen)-->saturated bonds
-used in the food industry b/c it helps in the preservation of food; changing the physical properties of fat (oils) changes the melting point which in turn can result in a better texture for the foods, especially when baking.

Trans vs. Cis Fatty Acids

Trans: a bond angle in which the orientation of the carbon chain is not disturbed and continues to be linear
--where there is a double bond/substrate, they are on opposite sides of the chain.

Cis: a bond angle in which the orientation of the carbon chain is changed and it becomes bent or “kinked”
--where there is a double bond/substrate, they are on the same side of the chain.

Probiotic vs. Prebiotic
Probiotic: when live microorganisms are consumed and aid in the digestion of food- often in yogurt
Prebiotic: Non-digestible food components (fiber) that selectively stimulate the growth of beneficial intestinal bacteria


Understand the differences between Omega-3 vs. Omega-6 in eicosanoids production and how this relates to health.

-The two essential fatty acids are: linoleic acid (omega-6 fatty acid) and alpha-linolenic acid (omega-3 fatty acid)

linoleic acid (omega-6 fatty acid)

linoleic acid



alpha-linolenic acid (omega-3 fatty acid)

alpha-linolenic acid

-to maintain health, we must consume these fatty acids from food sources because they cannot be synthesized by the body
*other fatty acids (like oleic acid), however, can be synthesized to some extent from the essential fatty acids
-human cells can only produce carbon-carbon double bonds starting at the 9th carbon from the methyl group (This is simply because the body does not make an enzyme that is able to place double bonds between the methyl end and the 9th carbon)
-these fatty acids play an important role in the formation of body structures, in the immune system, and in vision, they are vital to forming cell membranes and produce eicosanoids (hormonelike compounds) -EPA and DHA can be synthesized in the body from alpha-linoleic acid (which even further emphasizes how *essential* alpha-linoleic acid really is)

Digestion

Mouth- Mastication of food causes salivary amylase and lingual lipase to secrete and start the digestion of carbs and fatty acids, respectively. Food forms into a bolus. Peristalsis moves food from esophagus into stomach through lower esophageal sphincter.
Stomach- HCl deactivates salivary amylase and ligual lipase. Mucus from the throat prevents the stomach from digesting itself. G cells secrete gastrin which stimulates parietal and cheif cells. These cells secrete pepsinogen (activated by HCl) which produces pepsin for the breakdown of proteins. Gastric lipase continues the breakdown of lipids. Chyme continues through to the Small intestine.
Small Intestine- Major site of digestion. Chyme enters the duodenum with stimulates secretin and CCK. Secretin and CCK do 3 things:
1. stimulate pancreas to secrete bicarbonate and pancreatic enzymes (pancreatic juice)
2. Stimulates liver to secrete bile to gall bladder
3. gall bladder contracts and releases bile in duodenum.
Bicarbonate deactivates HCl so it won't denature the proteins.
Brush Border: prep of absorption is. Proteins: peptidase cleaves peptides to make individual amino acids.
Carbs: dissacharidases cleave dissacharides into mono.
Lipids: mixed micelles are formed. Contain bile acids cleaved.
Absorption: Transporters take mono, amino acids, phospholipids, cholesterol and small peptides into enterocyte. Mixed micelles diffuse into cellls.
Carbs: active absorbtion for glucose and galactose. transported to capilarries. Passive absorbsion for fructose.
Proteins: amino acids absorbed by amino acid transporters.
Lipids: get reformed to triglycerides and phospholipids packed into chylomicrons which are secreted into lacteal.
Protein Quality
Amino Acid Score x digestibilty
AAS x Digestibility

MORE TO COME!!!



Lovely_Kat
Lovely_Kat
Latest page update: made by Lovely_Kat , May 8 2009, 3:08 PM EDT (about this update About This Update Lovely_Kat Edited by Lovely_Kat


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